Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740803 | 0.89 | MAPK14 (0.41) | METMAPK14KDRCYP3A4CYP2D6 | |
| SCHEMBL5740106 | 0.88 | SYK (0.37) | METMAPK14KDRCYP3A4CYP2D6 | |
| SCHEMBL5740055 | 0.87 | MAPT (0.35) | METMAPK14KDR | |
| SCHEMBL5740319 | 0.87 | KDR (0.37) | METMAPK14KDRCYP3A4CYP2D6 | |
| SCHEMBL5739297 | 0.86 | MAPT (0.34) | METMAPK14KDRCYP3A4CYP2D6 | |
| SCHEMBL5740995 | 0.85 | MET (0.33) | METKDRCYP3A4 | |
| SCHEMBL5740762 | 0.85 | KMT2A (0.32) | METKDRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4047341 | 0.85 | MAPK14 (0.52) | MAPK14KDR | |
| SCHEMBL5740494 | 0.83 | KDR (0.35) | METMAPK14KDRCYP3A4CYP2D6 | |
| SCHEMBL5739782 | 0.83 | MAPT (0.36) | KDRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |