Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.30 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740106 | 0.91 | SYK (0.37) | KMT2AMEN1MAPTTP53ALDH1A1 | |
| SCHEMBL5739297 | 0.89 | MAPT (0.34) | MAPTTP53ALDH1A1METKDM4E | |
| SCHEMBL14469831 | 0.87 | MAPK14 (0.42) | POLBKDR | |
| SCHEMBL4053348 | 0.87 | MAPK14 (0.42) | POLBKDR | |
| SCHEMBL5739782 | 0.86 | MAPT (0.36) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL5739596 | 0.85 | MET (0.39) | METKDRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5740995 | 0.85 | MET (0.33) | METKDRCYP3A4 | |
| SCHEMBL5738334 | 0.85 | KDM4E (0.43) | MAPTTP53ALDH1A1KDM4E | |
| SCHEMBL5738802 | 0.85 | KDR (0.32) | MAPTTP53METKDRCYP3A4 | |
| SCHEMBL5740803 | 0.85 | MAPK14 (0.41) | METKDRCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |