Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.33 |
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14451976 | 0.93 | MET (0.33) | METKDRCYP3A4BRD4 | |
| SCHEMBL5740106 | 0.87 | SYK (0.37) | METKDRCYP3A4 | |
| SCHEMBL4049399 | 0.87 | KDR (0.45) | KDR | |
| SCHEMBL5739297 | 0.86 | MAPT (0.34) | METKDRCYP3A4 | |
| SCHEMBL5739596 | 0.85 | MET (0.39) | METKDRCYP3A4 | |
| SCHEMBL5740762 | 0.85 | KMT2A (0.32) | METKDRCYP3A4 | |
| SCHEMBL5740803 | 0.85 | MAPK14 (0.41) | METKDRCYP3A4BRD4 | |
| SCHEMBL5740055 | 0.83 | MAPT (0.35) | METKDR | |
| SCHEMBL5738802 | 0.83 | KDR (0.32) | METKDRCYP3A4 | |
| SCHEMBL5740319 | 0.83 | KDR (0.37) | METKDRCYP3A4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |