SCHEMBL5740251

SCHEMBL5740251

CC(C)(C)OC(=O)N1CCC(CN2CCN(S(=O)(=O)C3=Cc4ccc(Cl)cc4OC3)CC2=O)(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F13A1 P00488 3/20 0.36
TGM2 P21980 3/20 0.36
TGM1 P22735 3/20 0.36
TGM3 Q08188 1/20 0.36
MAPT P10636 1/20 0.35
UTS2R Q9UKP6 3/20 0.35
GPR119 Q8TDV5 6/20 0.34
STS P08842 1/20 0.33
PKM P14618 1/20 0.32
MMP2 P08253 1/20 0.32
MMP13 P45452 1/20 0.32
MMP14 P50281 1/20 0.32
ADAM17 P78536 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6896840 0.96 PKM (0.37) F13A1TGM2TGM1TGM3MAPT
SCHEMBL5742053 0.94 F13A1 (0.37) F13A1TGM2TGM1TGM3MAPT
SCHEMBL6896236 0.91 UTS2R (0.37) F13A1TGM2TGM1TGM3MAPT
SCHEMBL6895758 0.88 TGM2 (0.36) F13A1TGM2TGM1TGM3MAPT
SCHEMBL6893668 0.86 ALDH1A1 (0.35) MAPT
SCHEMBL6892977 0.85 UTS2R (0.41) F13A1TGM2TGM1TGM3MAPT
SCHEMBL5742580 0.83 UTS2R (0.37) F13A1TGM2TGM1TGM3MAPT
SCHEMBL5734380 0.82 TGM2 (0.48) F13A1TGM2TGM1TGM3MAPT
Hydrochloric Acid SCHEMBL6895332 0.81 F10 (0.34)
SCHEMBL5741347 0.81 STS (0.40) F13A1TGM2TGM1MAPTGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109200-B2 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-09-19 US disclosed
EP-1340753-B1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-01-11 EP disclosed
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-26 US disclosed
EP-1340753-A1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof CFH, F11, F2 F13A1 18/4885TGM2 1508/4885TGM1 327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.