Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740319 | 0.93 | KDR (0.37) | CHEK1MAPK14BRD4KDREGLN2 | |
| SCHEMBL4052615 | 0.86 | KDR (0.44) | CHEK1MAPK14KDR | |
| SCHEMBL5740055 | 0.85 | MAPT (0.35) | MAPK14KDRMETKDM4EALDH1A1 | |
| SCHEMBL5740494 | 0.85 | KDR (0.35) | MAPK14KDRMAP4K4RETPDGFRB | |
| SCHEMBL5738802 | 0.85 | KDR (0.32) | MAPK14KDRMAP4K4RETPDGFRB | |
| SCHEMBL5739596 | 0.82 | MET (0.39) | MAPK14KDRMAP4K4RETPDGFRB | |
| SCHEMBL5740803 | 0.81 | MAPK14 (0.41) | MAPK14BRD4KDRMAP4K4RET | |
| SCHEMBL5740106 | 0.80 | SYK (0.37) | MAPK14KDRMAP4K4RETPDGFRB | |
| SCHEMBL4048222 | 0.79 | KDR (0.43) | MAPK14KDRAURKADAPK3PRKD3 | |
| SCHEMBL5739297 | 0.79 | MAPT (0.34) | MAPK14KDRMAP4K4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |