Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.31 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740106 | 0.87 | SYK (0.37) | KDRFGFR1METCYP3A4CYP2D6 | |
| SCHEMBL4047091 | 0.86 | KDR (0.44) | KDRMAPK14 | |
| SCHEMBL5739297 | 0.86 | MAPT (0.34) | KDRFGFR1METCYP3A4CYP2D6 | |
| SCHEMBL5740762 | 0.85 | KMT2A (0.32) | KDRFGFR1METCYP3A4CYP2D6 | |
| SCHEMBL5740055 | 0.85 | MAPT (0.35) | KDRMETMAPTMAPK14 | |
| SCHEMBL5740494 | 0.85 | KDR (0.35) | KDRFGFR1METCYP3A4CYP2D6 | |
| SCHEMBL5740281 | 0.85 | CHEK1 (0.42) | KDRFGFR1KITMETMAP4K4 | |
| SCHEMBL5740995 | 0.83 | MET (0.33) | KDRMETCYP3A4 | |
| SCHEMBL4115186 | 0.83 | KDR (0.33) | KDRFGFR1MAPK14 | |
| SCHEMBL5739782 | 0.82 | MAPT (0.36) | KDRCYP3A4TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |