Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.50 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | ACR | P10323 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26564348 | 0.87 | LMNA (0.61) | ELANELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL16099852 | 0.86 | PARP1 (0.50) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL28381698 | 0.84 | CES2 (0.50) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL15994033 | 0.82 | MTNR1B (0.49) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL15967555 | 0.82 | MTNR1B (0.46) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL15987278 | 0.82 | MTNR1B (0.46) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL361383 | 0.82 | LMNA (0.66) | CES2CES1MTNR1BMTNR1ALMNA | |
| SCHEMBL28704390 | 0.82 | PTGS1 (0.57) | MTNR1BELANELMNAMEN1KMT2A | |
| SCHEMBL10720409 | 0.81 | CYP3A4 (0.70) | ELANELMNAESR1ESR2MEN1 | |
| SCHEMBL12119292 | 0.81 | LMNA (0.70) | ELANELMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620438-A1 | TRICYCLIC INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004094430-A1 | TRICYCLIC INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER’S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-11-04 | — | — | WO | disclosed |