Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MTTP | P55157 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21131047 | 0.86 | NOS3 (0.58) | HRH3KCNH2MEN1KMT2AHPGD | |
| SCHEMBL5464853 | 0.86 | MEN1 (0.70) | HRH3KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL32660728 | 0.86 | KCNH2 (0.51) | HRH3KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL23252438 | 0.81 | KMT2A (0.55) | HRH3MEN1KMT2AKDM4EMLLT1 | |
| SCHEMBL32660745 | 0.80 | MAPT (0.64) | HRH3KCNH2MEN1KMT2A | |
| SCHEMBL30677754 | 0.80 | KMT2A (0.60) | HRH3MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL6559744 | 0.80 | KDM4E (0.68) | HRH3MEN1KMT2ATSHRKDM4E | |
| SCHEMBL5217325 | 0.80 | KDM4E (0.68) | HRH3MEN1KMT2ATSHRKDM4E | |
| SCHEMBL4559263 | 0.78 | TP53 (0.63) | MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL3126965 | 0.78 | NPC1 (0.57) | HRH3MEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673059-A2 | ALKANOL AND CYCLOALKANOL-AMINE DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037207-A2 | ARYLALKYL-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS AMELIORATED BY MONOAMINE REUPTAKE INCLUDING VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |