Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | PDE1A | P54750 | 4/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740742 | 0.86 | ADORA3 (0.48) | PDE5AADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5739685 | 0.77 | PDE5A (0.41) | PDE5AADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5742504 | 0.71 | ALDH1A1 (0.55) | PDE5APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL8576951 | 0.69 | ADORA3 (0.61) | PDE5AADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL14927363 | 0.68 | PDE1A (0.54) | ADORA3ADORA1ADORA2AADORA2BPDE1A | |
| SCHEMBL30134302 | 0.67 | ALDH1A1 (0.44) | PDE1APDE1BPDE1CMAPK1NPSR1 | |
| SCHEMBL30134222 | 0.67 | HSP90AA1 (0.40) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL12963694 | 0.66 | HDAC1 (0.67) | ADORA3ADORA1PDE1APDE1BPDE1C | |
| SCHEMBL5741729 | 0.66 | ADORA2A (0.39) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5740121 | 0.66 | PDE5A (0.45) | PDE5AADORA3ADORA1PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1637532-A1 | FUSED PYRIMIDINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | INSR, GPR119, NPY4R | PDE5A 1470/4885ADORA3 275/4885ADORA1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.