Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969945 | 1.00 | KMT2A (0.53) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL14737622 | 1.00 | KMT2A (0.53) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL22979065 | 0.90 | TDP1 (0.57) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL2946356 | 0.90 | TDP1 (0.57) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL1022916 | 0.88 | KMT2A (0.55) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL13165128 | 0.88 | TDP1 (0.58) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL13165125 | 0.88 | TDP1 (0.58) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL24221821 | 0.87 | KMT2A (0.53) | KMT2ACTSSCTSKCA2CA1 | |
| SCHEMBL13112935 | 0.86 | TDP1 (0.65) | KMT2ATDP1CTSSCTSKCA2 | |
| SCHEMBL13112915 | 0.86 | TDP1 (0.65) | KMT2ATDP1CTSSCTSKCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470763-B2 | Alpha-amino-N-substituted amides, pharmaceutical composition containing them and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES (CN) | 2013-06-25 | — | — | US | disclosed |
| US-20110021624-A1 | Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2011-01-27 | — | — | US | disclosed |
| EP-2233467-A1 | ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-09-29 | — | — | EP | disclosed |
| US-7589115-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589115-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-7345074-B2 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345074-B2 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7304067-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304067-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1560830-B1 | DERIVATIVES OF [6, 7-DIHYDRO-5H-IMIDAZO[1,2 - A]IMIDAZOLE -3 -SULFONYLAMINO]-PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKOINTEGRINS | BOEHRINGER INGELHEIM PHARMA (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1712553-A2 | Derivates of [6, 7-dihydro - 5H - imidazo[1,2- alpha]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of CAMS and leukointegrins | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1560830-A2 | DERIVATIVES OF [6, 7 - DIHYDRO - 5H - IMIDAZO [1,2 - A] IMIDAZOLE - 3 - SULFONYLAMINO]- PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKOINTEGRINS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041827-A2 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-α] IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKO INTEGRINS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021624-A1 | Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof | AADAT, ASNS, AANAT | KMT2A 1681/4885TDP1 2444/4885CTSS 3159/4885 |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | HPGDS, PTGIS, API5 | KMT2A 2222/4885TDP1 4210/4885CTSS 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.