Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739936 | 0.87 | ADORA2B (0.57) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL5740591 | 0.73 | ALDH1A1 (0.46) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL5741227 | 0.71 | ADORA2B (0.68) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL10429700 | 0.69 | ALDH1A1 (0.56) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL5785083 | 0.68 | KDM4E (0.41) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL23401315 | 0.64 | MEN1 (0.82) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL8541305 | 0.64 | ADORA2B (0.56) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL29446410 | 0.62 | KCNH2 (0.69) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL17446140 | 0.62 | ALDH1A1 (0.54) | ADORA2BADORA3ADORA1ADORA2AALDH1A1 | |
| SCHEMBL9420336 | 0.62 | ADORA2A (0.55) | ADORA2BADORA3ADORA1ADORA2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1637532-A1 | FUSED PYRIMIDINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | INSR, GPR119, NPY4R | ADORA2B 1074/4885ADORA3 275/4885ADORA1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.