Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723491 | 0.92 | HTR1A (0.55) | HTR1AHTR3AP2RY14HTR2CKDM4E | |
| Trifluoroacetic Acid SCHEMBL5744420 | 0.83 | HTR1A (0.43) | HTR1AHTR3AP2RY14HTR2CKDM4E | |
| Trifluoroacetic Acid SCHEMBL3548477 | 0.82 | P2RY14 (0.43) | HTR1AHTR3AP2RY14HTR2CKDM4E | |
| SCHEMBL3539172 | 0.79 | HTR2C (0.51) | HTR1AHTR3AHTR2CSIGMAR1SLC6A2 | |
| Trifluoroacetic Acid SCHEMBL3544301 | 0.79 | SLC6A2 (0.41) | HTR1AP2RY14HTR2CSLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL3548154 | 0.78 | HTR1A (0.47) | HTR1AHTR3AHTR2CKDM4EALDH1A1 | |
| SCHEMBL5742408 | 0.77 | KDM4E (0.48) | HTR1AHTR3AKDM4EALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL3544758 | 0.76 | HTR1A (0.46) | HTR1AHTR3AHTR2CALDH1A1MAPT | |
| SCHEMBL3548275 | 0.76 | HTR2C (0.49) | HTR1AHTR3AP2RY14HTR2CADRB3 | |
| Trifluoroacetic Acid SCHEMBL3540769 | 0.76 | HTR2C (0.40) | HTR1AHTR3AP2RY14HTR2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |