Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 9/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.44 |
| ▸ | ITGAL | P20701 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3540769 | 0.90 | HTR2C (0.40) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL3546218 | 0.89 | HTR2C (0.41) | HTR1AHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3546875 | 0.89 | HTR1A (0.55) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL3544105 | 0.87 | HTR1A (0.50) | HTR1AHTR3AHTR2CSLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL5669615 | 0.81 | DPP4 (0.43) | HTR1AKMT2AHTR2CSLC6A2SLC6A4 | |
| SCHEMBL3538723 | 0.79 | SLC6A2 (0.45) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3548204 | 0.79 | SLC6A2 (0.48) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3544759 | 0.79 | RBP4 (0.41) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5742637 | 0.78 | SLC6A2 (0.38) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3541861 | 0.77 | SLC6A2 (0.47) | HTR1ACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732463-B2 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2010-06-08 | — | — | US | disclosed |
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | H.LUNDBECK A/S (DK) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | HTR4, HTR5A, TPH1 | HTR1A 11/4885CYP1A2 833/4885CYP3A4 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.