Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 6/20 | 0.43 |
| ▸ | DRD5 | P21918 | 4/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 5/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541652 | 0.92 | HTR2C (0.44) | P2RY14DRD5TMEM97ADRB3ADRA2B | |
| Trifluoroacetic Acid SCHEMBL5744789 | 0.85 | HTR1A (0.44) | HTR2CKDM1AHTR1AHTR3ASLC6A2 | |
| Trifluoroacetic Acid SCHEMBL3544769 | 0.85 | HTR1A (0.47) | KDM1AHTR1AHTR3ASLC6A2SLC6A3 | |
| Oxalic Acid SCHEMBL3547105 | 0.83 | P2RY14 (0.41) | P2RY14DRD5TMEM97ADRB3ADRA2B | |
| Trifluoroacetic Acid SCHEMBL5742404 | 0.82 | HTR1A (0.48) | P2RY14DRD5TMEM97ADRB3ADRA2B | |
| Oxalic Acid SCHEMBL3547675 | 0.82 | HTR1A (0.46) | P2RY14HTR2CHTR1AHTR3ASLC6A2 | |
| Trifluoroacetic Acid SCHEMBL3543680 | 0.82 | SLC6A2 (0.43) | KDM1AHTR1AHTR3ASLC6A2SLC6A3 | |
| SCHEMBL3542542 | 0.81 | HTR2C (0.44) | HTR2CHTR1AHTR3ACA1CA2 | |
| SCHEMBL3549260 | 0.80 | HTR1A (0.44) | HTR2CHTR1AHTR3ACA1CA2 | |
| SCHEMBL3548483 | 0.79 | ALDH1A1 (0.39) | KDM1ACA1CA2PTGDR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732463-B2 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2010-06-08 | — | — | US | disclosed |
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | H.LUNDBECK A/S (DK) | 2006-05-11 | — | — | US | disclosed |
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | HTR4, HTR5A, TPH1 | P2RY14 1261/4885DRD5 31/4885TMEM97 920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.