Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478544 | 1.00 | MAPT (0.39) | MAPTSMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL5462316 | 1.00 | MAPT (0.39) | MAPTSMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL5466436 | 0.86 | MAPT (0.48) | MAPTSMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL6477993 | 0.86 | MAPT (0.48) | MAPTSMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL6478181 | 0.85 | MAPT (0.39) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6335663 | 0.80 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL31639877 | 0.78 | ALDH1A1 (0.44) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL5742737 | 0.77 | MAPT (0.51) | MAPTSMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL5744587 | 0.77 | MAPT (0.51) | MAPTSMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL4780908 | 0.76 | NFKB1 (0.39) | NFKB1NFKB2RELAKDM4DGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646630-A1 | OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005422-A1 | OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2005-01-20 | — | — | WO | disclosed |