Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744524 | 1.00 | RIPK1 (0.39) | RIPK1HSP90AA1HSP90AB1GAATSHR | |
| SCHEMBL5747935 | 0.92 | HSP90AA1 (0.44) | RIPK1HSP90AA1HSP90AB1ALDH1A1ITGB3 | |
| SCHEMBL6310123 | 0.92 | HSP90AA1 (0.44) | RIPK1HSP90AA1HSP90AB1ALDH1A1ITGB3 | |
| SCHEMBL6318100 | 0.80 | ITGB3 (0.38) | RIPK1HSP90AA1HSP90AB1GAATSHR | |
| SCHEMBL6318104 | 0.80 | ITGB3 (0.38) | RIPK1HSP90AA1HSP90AB1GAATSHR | |
| SCHEMBL5746786 | 0.78 | HSP90AA1 (0.43) | RIPK1HSP90AA1HSP90AB1ALDH1A1ITGB3 | |
| SCHEMBL5746789 | 0.78 | HSP90AA1 (0.43) | RIPK1HSP90AA1HSP90AB1ALDH1A1ITGB3 | |
| SCHEMBL2800961 | 0.77 | BRD4 (0.40) | RIPK1HSP90AA1HSP90AB1ITGB3ITGB1 | |
| SCHEMBL6317365 | 0.76 | HSP90AA1 (0.44) | RIPK1HSP90AA1HSP90AB1ITGB3ITGB1 | |
| SCHEMBL17509670 | 0.76 | OPRD1 (0.43) | RIPK1HSP90AA1HSP90AB1ITGB3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638935-A1 | NK1 ANTAGONIST | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | claimed |
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | claimed |
| WO-2004110996-A1 | NK1 ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | claimed |
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | RIPK1 2280/4885HSP90AA1 3787/4885HSP90AB1 3339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.