Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28264517 | 0.81 | KDM4E (0.46) | GRM2KDM4EALOX15HTTMAPT | |
| SCHEMBL3281879 | 0.81 | KDM4E (0.60) | KDM4EALOX15HTTSMN1; SMN2MAPT | |
| SCHEMBL2775988 | 0.78 | ALOX15 (0.58) | GRM2KDM4EALOX15HTTSMN1; SMN2 | |
| SCHEMBL163381 | 0.77 | SMN1; SMN2 (0.53) | KDM4ESMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL27754847 | 0.77 | GRM2 (0.47) | IGF1RGRM2KDM4EALOX15HTT | |
| SCHEMBL2708959 | 0.75 | GRM2 (0.63) | GRM2 | |
| SCHEMBL4304080 | 0.74 | SMN1; SMN2 (0.57) | KDM4EHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL164886 | 0.71 | ALDH1A1 (0.55) | GRM2KDM4EHTTMAPTALDH1A1 | |
| SCHEMBL23496954 | 0.71 | IGF1R (0.44) | IGF1RKDM4EMAPTALDH1A1 | |
| SCHEMBL9495292 | 0.70 | MAOA (0.47) | IGF1RKDM4ESMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725529-A1 | BIS BICYCLIC AMIDES AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROPATIC PAIN | Amgen Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005070885-A1 | BIS BICYCLIC AMIDES AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROPATIC PAIN | AMGEN INC. (US) | 2005-08-04 | — | — | WO | disclosed |