Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745432 | 0.84 | LMNA (0.48) | PTPN1SMN1; SMN2PKMLMNAKMT2A | |
| SCHEMBL5745391 | 0.84 | GFPT1 (0.49) | KMT2AMEN1CYP1A2HSD17B10VNN1 | |
| SCHEMBL5745161 | 0.83 | KMT2A (0.48) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5745387 | 0.82 | RAB9A (0.50) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5743070 | 0.82 | VNN1 (0.49) | SMN1; SMN2PKMCYP1A2NPC1VNN1 | |
| SCHEMBL5744347 | 0.82 | VNN1 (0.49) | SMN1; SMN2PKMCYP1A2NPC1VNN1 | |
| SCHEMBL5744619 | 0.81 | GFPT1 (0.49) | SMN1; SMN2LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL5743882 | 0.81 | GFPT1 (0.49) | CYP1A2NPC1KDM4EVNN1GFPT1 | |
| Trifluoroacetic Acid SCHEMBL5767994 | 0.80 | GFPT1 (0.51) | PTPN1PKMLMNACYP1A2KDM4E | |
| SCHEMBL5746006 | 0.80 | GFPT1 (0.47) | LMNAMAPTKMT2ACYP1A2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631551-A2 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS GFAT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-08 | — | — | EP | claimed |
| WO-2004101528-A2 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS GFAT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | claimed |
| EP-1631551-A2 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS GFAT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004101528-A2 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS GFAT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | disclosed |