Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745562 | 0.78 | MEN1 (0.45) | ADRA1BHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL5745558 | 0.78 | MEN1 (0.45) | ADRA1BHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL5748380 | 0.76 | SMN1; SMN2 (0.38) | ADRA1BHTR1AHTR7ADRA1AALDH1A1 | |
| SCHEMBL12879728 | 0.67 | DRD2 (0.62) | ADRA1BHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL5748586 | 0.67 | HTR3E (0.41) | ADRA1BDRD2ADRA1AALDH1A1LMNA | |
| SCHEMBL5748582 | 0.65 | HTR3E (0.41) | ADRA1BDRD2ADRA1AALDH1A1LMNA | |
| SCHEMBL5267087 | 0.64 | DRD2 (0.59) | ADRA1BHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL22753600 | 0.63 | ADRA1D (0.52) | ADRA1BHTR1ADRD2ADRA1AALDH1A1 | |
| SCHEMBL16440194 | 0.62 | DRD2 (0.38) | HTR1ADRD2HTR2AHTR7ADRA1A | |
| SCHEMBL14006927 | 0.62 | ALDH1A1 (0.60) | HTR1ADRD2HTR2AHTR7ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673089-A2 | PHENYL-PIPERAZINE DERIVATIVES AS MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmaceuticals Incorporated (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030188-A2 | PHENYL-PIPERAZINE DERIVATIVES AS MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |