Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 7/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | LAP3 | P28838 | 3/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL574780 | 1.00 | FDPS (0.43) | FDPSMETAP1LAP3SMPD1 | |
| Phosphoric Acid SCHEMBL2580447 | 0.86 | LAP3 (0.39) | FDPSLAP3 | |
| Water SCHEMBL573386 | 0.86 | — | — | |
| SCHEMBL573231 | 0.86 | — | — | |
| Water SCHEMBL573385 | 0.86 | TSHR (0.37) | — | |
| SCHEMBL464424 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL16974730 | 0.84 | — | — | |
| SCHEMBL9340203 | 0.77 | FDPS (0.35) | FDPSMETAP1 | |
| SCHEMBL7157362 | 0.77 | TSHR (0.35) | — | |
| Trifluoroacetic Acid SCHEMBL3458308 | 0.76 | DPP8 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601175-A1 | A NOVEL CRYSTALLINE COMPOUND COMPRISING SAXAGLIPTIN AND PHOSPHORIC ACID | Sandoz AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017028-A1 | A NOVEL CRYSTALLINE COMPOUND COMPRISING SAXAGLIPTIN AND PHOSPHORIC ACID | SANDOZ AG (CH) | 2012-02-09 | — | — | WO | disclosed |