Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746071 | 1.00 | P2RX7 (0.47) | P2RX7SIGMAR1CHRM3MEN1KMT2A | |
| SCHEMBL5746277 | 0.90 | ALDH1A1 (0.47) | P2RX7MEN1KMT2AADORA1CHRM1 | |
| SCHEMBL5746272 | 0.90 | ALDH1A1 (0.47) | P2RX7MEN1KMT2AADORA1CHRM1 | |
| SCHEMBL9483331 | 0.83 | P2RX7 (0.48) | P2RX7MEN1KMT2AADORA1CHRM1 | |
| SCHEMBL5746743 | 0.83 | GRIN2D (0.48) | P2RX7MEN1KMT2AOPRK1 | |
| SCHEMBL5746736 | 0.83 | GRIN2D (0.48) | P2RX7MEN1KMT2AOPRK1 | |
| SCHEMBL5770430 | 0.82 | P2RX7 (0.46) | P2RX7ADORA1 | |
| SCHEMBL5747677 | 0.82 | P2RX7 (0.48) | P2RX7MEN1KMT2AADORA1 | |
| SCHEMBL5747674 | 0.82 | P2RX7 (0.48) | P2RX7MEN1KMT2AADORA1 | |
| SCHEMBL5770422 | 0.82 | P2RX7 (0.46) | P2RX7ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487449-A4 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-08-23 | — | — | EP | claimed |
| EP-1487449-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | King Pharmaceuticals Research and Development Inc. (US) | 2004-12-22 | — | — | EP | claimed |
| US-20030181452-A1 | Tyrosyl derivatives and their use as P2X7 receptor modulators | CREDIT SUISSE AG | 2003-09-25 | — | — | US | claimed |
| WO-2003059353-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2003-07-24 | — | — | WO | claimed |
| EP-1487449-A4 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-08-23 | — | — | EP | disclosed |
| US-7094895-B2 | Tyrosyl derivatives and their use as P2X7 receptor modulators | KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1487449-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | King Pharmaceuticals Research and Development Inc. (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20030181452-A1 | Tyrosyl derivatives and their use as P2X7 receptor modulators | CREDIT SUISSE AG | 2003-09-25 | — | — | US | disclosed |
| WO-2003059353-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181452-A1 | Tyrosyl derivatives and their use as P2X7 receptor modulators | P2RX7, P2RX3, P2RX5 | P2RX7 1/4885SIGMAR1 829/4885CHRM3 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.