Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789857 | 0.79 | ABCB11 (0.36) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL844427 | 0.79 | ABCB11 (0.38) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL6849453 | 0.74 | AGTR1 (0.64) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL3638790 | 0.73 | AGTR1 (0.39) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL9291479 | 0.71 | PARP1 (0.35) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL8836872 | 0.71 | BRS3 (0.33) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL3821755 | 0.70 | AGTR2 (0.45) | PPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL9638150 | 0.68 | ABCB11 (0.37) | PPARGABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL4119807 | 0.67 | DHODH (0.44) | — | |
| SCHEMBL3400645 | 0.66 | PPARG (0.51) | PPARGCYP3A4ADORA3ADRA2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718641-A2 | BENZIMIDAZOLE DERIVATIVE AND ITS USE AS AII RECEPTOR ANTAGONIST | Takeda Pharmaceutical Company Limited (JP) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080384-A2 | BENZIMIDAZOLE DERIVATIVE AND USE AS AII RECEPTOR ANTAGONIST | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-01 | — | — | WO | disclosed |