Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540397 | 0.92 | CMKLR1 (0.48) | AGTR2CMKLR1LTB4R2 | |
| SCHEMBL8836872 | 0.84 | BRS3 (0.33) | AGTR2LTB4R2PPARGAGTR1 | |
| SCHEMBL789857 | 0.79 | ABCB11 (0.36) | AGTR2CMKLR1LTB4R2PPARGAGTR1 | |
| SCHEMBL9291479 | 0.78 | PARP1 (0.35) | AGTR2LTB4R2PPARGAGTR1 | |
| SCHEMBL844427 | 0.76 | ABCB11 (0.38) | AGTR2LTB4R2PPARGAGTR1 | |
| SCHEMBL965217 | 0.74 | AGTR2 (0.75) | AGTR2LTB4R2PPARGAGTR1 | |
| SCHEMBL17424355 | 0.72 | AGTR2 (0.60) | AGTR2PPARG | |
| SCHEMBL3400645 | 0.69 | PPARG (0.51) | AGTR2PPARGAGTR1 | |
| SCHEMBL683359 | 0.69 | AGTR2 (0.57) | AGTR2PPARGAGTR1 | |
| SCHEMBL3638790 | 0.69 | AGTR1 (0.39) | AGTR2LTB4R2PPARGAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857457-B1 | Benzimidazole derivative and its use as AII receptor antagonist | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | disclosed |
| EP-1857457-A2 | Benzimidazole derivative and its use as AII receptor antagonist | Takeda Pharmaceutical Company Limited (JP) | 2007-11-21 | — | — | EP | disclosed |