Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747639 | 0.96 | HTR1B (0.61) | HTR1BADRB2ALKBH5FTOSLC6A4 | |
| SCHEMBL5771872 | 0.88 | HTR1B (0.60) | HTR1BADRB2ALKBH5FTOSLC6A4 | |
| SCHEMBL5770352 | 0.88 | HRH1 (0.58) | HTR1BALKBH5FTOSLC6A4HRH1 | |
| SCHEMBL5749824 | 0.86 | HTR1B (0.57) | HTR1BALKBH5FTOSLC6A4HRH1 | |
| SCHEMBL5747516 | 0.82 | HTR1B (0.54) | HTR1BALKBH5FTOKMT2AKCNA3 | |
| SCHEMBL15466278 | 0.81 | ALKBH5 (0.54) | ALKBH5FTOKMT2AGPR3 | |
| SCHEMBL5748798 | 0.80 | HTR1B (0.53) | HTR1BALKBH5FTOKMT2AKCNA3 | |
| SCHEMBL5746733 | 0.80 | HTR1B (0.51) | HTR1BADRB2SLC6A4HRH1KCNA3 | |
| SCHEMBL5745853 | 0.79 | HTR1B (0.53) | HTR1BADRB2SLC6A4HRH1KMT2A | |
| SCHEMBL5748021 | 0.78 | HTR1B (0.50) | HTR1BALKBH5FTOSLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |