Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747516 | 0.93 | HTR1B (0.54) | HTR1BALKBH5FTOKDM4EGPR3 | |
| SCHEMBL15466278 | 0.83 | ALKBH5 (0.54) | ALKBH5FTOKDM4EGPR3TP53 | |
| SCHEMBL5749824 | 0.82 | HTR1B (0.57) | HTR1BALKBH5FTOKDM4EGPR3 | |
| SCHEMBL5770352 | 0.81 | HRH1 (0.58) | HTR1BALKBH5FTOGPR3HTR6 | |
| SCHEMBL5747639 | 0.81 | HTR1B (0.61) | HTR1BALKBH5FTOGPR3HTR6 | |
| SCHEMBL5748859 | 0.80 | TDP1 (0.57) | HTR6TSHR | |
| SCHEMBL5747747 | 0.80 | HTR1B (0.56) | HTR1BALKBH5FTOGPR3KCNA3 | |
| SCHEMBL5748021 | 0.80 | HTR1B (0.50) | HTR1BALKBH5FTOKDM4EGPR3 | |
| SCHEMBL5747367 | 0.79 | TDP1 (0.56) | HTR6TSHR | |
| SCHEMBL5771872 | 0.79 | HTR1B (0.60) | HTR1BALKBH5FTOHTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |