Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748386 | 1.00 | DRD2 (0.49) | DRD2DRD3IGF1RKDM4EALDH1A1 | |
| SCHEMBL5748380 | 0.74 | SMN1; SMN2 (0.38) | KDM4EALDH1A1PLA2G1BRAB9AATG4B | |
| SCHEMBL5745562 | 0.74 | MEN1 (0.45) | DRD2DRD3ALDH1A1HTR1ALMNA | |
| SCHEMBL5745558 | 0.74 | MEN1 (0.45) | DRD2DRD3ALDH1A1HTR1ALMNA | |
| SCHEMBL16063427 | 0.69 | DRD2 (0.71) | DRD2DRD3IGF1RHTR1ADRD4 | |
| SCHEMBL9565835 | 0.69 | KDM4E (0.66) | DRD2DRD3KDM4EALDH1A1PLA2G1B | |
| SCHEMBL10533306 | 0.69 | IGF1R (0.62) | DRD2DRD3IGF1RKDM4EALDH1A1 | |
| SCHEMBL28396664 | 0.68 | ADRB1 (0.71) | DRD2DRD3KDM4EALDH1A1PLA2G1B | |
| SCHEMBL13898923 | 0.66 | ADRB1 (0.53) | DRD2DRD3KDM4EALDH1A1PLA2G1B | |
| SCHEMBL30001672 | 0.65 | HTR7 (0.75) | KDM4EALDH1A1LMNAHTR7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673089-A2 | PHENYL-PIPERAZINE DERIVATIVES AS MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmaceuticals Incorporated (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030188-A2 | PHENYL-PIPERAZINE DERIVATIVES AS MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |