Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785894 | 0.87 | DRD2 (0.77) | DRD2DRD3DRD4ADRB1 | |
| SCHEMBL2783299 | 0.86 | DRD2 (0.56) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL2784889 | 0.84 | DRD2 (0.55) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL2782686 | 0.84 | DRD2 (0.55) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL2784856 | 0.84 | DRD2 (0.55) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL28396664 | 0.83 | ADRB1 (0.71) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL844998 | 0.82 | DRD2 (0.52) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL845243 | 0.82 | DRD2 (0.52) | KDM4ELMNAALDH1A1PLA2G1BRAB9A | |
| SCHEMBL12126914 | 0.81 | GAA (0.58) | LMNAALDH1A1DRD2DRD3CHRNA7 | |
| SCHEMBL2782876 | 0.81 | DRD2 (0.51) | KDM4ELMNAALDH1A1PLA2G1BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765447-B1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2023-07-12 | — | — | EP | disclosed |
| EP-2445502-B2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS | ALKERMES PHARMA IRELAND LTD (IE) | 2022-09-28 | — | — | EP | disclosed |
| US-20210332046-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-10-28 | — | — | US | disclosed |
| US-11155551-B2 | Nicotinic acetylcholine receptor silent agonists | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20200247804-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2020-08-06 | — | — | US | disclosed |
| US-10662191-B2 | Nicotinic acetylcholine receptor silent agonists | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20180298002-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2018-10-18 | — | — | US | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2017066558-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| US-7915405-B2 | 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives for therapeutic agent of antiinflammatory disease, method thereof for preparation, therapeutic agent for antiinflammatory disease induced by SPC activity containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-03-29 | — | — | US | disclosed |
| US-20100267698-A1 | Benzimidazole and Pyridylimidazole Derivatives | NEUROGEN CORPORATION | 2010-10-21 | — | — | US | disclosed |
| US-20100145043-A1 | 2,4-Disubstituted-5-Aminocarbonyl-1,3-Thiazole Derivatives For Therapeutic Agent Of Antiinflammatory Disease, Method Thereof For Preparation, Therapeutic Agent For Antiinflammatory Disease Induced By SPC Activity Containing The Same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
| US-7642267-B2 | Benzimidazole and pyridylimidazole derivatives | NEUROGEN CORPORATION (US) | 2010-01-05 | — | — | US | disclosed |
| US-20080227793-A1 | Benzimidazole and Pyridylimidazole Derivatives | NEUROGEN CORPORATION | 2008-09-18 | — | — | US | disclosed |
| US-7300945-B2 | Benzimidazole and pyridylimidazole derivatives | NEUROGEN CORPORATION (US) | 2007-11-27 | — | — | US | disclosed |
| US-7166572-B1 | Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166572-B1 | Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| EP-0548798-A1 | Antiviral agent | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267698-A1 | Benzimidazole and Pyridylimidazole Derivatives | GABBR1, GABBR2, GABRA2 | KDM4E 1996/4885LMNA 2796/4885ALDH1A1 470/4885 |
| US-20080227793-A1 | Benzimidazole and Pyridylimidazole Derivatives | GABBR1, GABBR2, GABRA2 | KDM4E 1996/4885LMNA 2796/4885ALDH1A1 470/4885 |
| US-20100145043-A1 | 2,4-Disubstituted-5-Aminocarbonyl-1,3-Thiazole Derivatives For Therapeutic Agent Of Antiinflammatory Disease, Method Thereof For Preparation, Therapeutic Agent For Antiinflammatory Disease Induced By SPC Activity Containing The Same | HRH4, TSLP, IL1R1 | KDM4E 2666/4885LMNA 4063/4885ALDH1A1 965/4885 |
| US-20180298002-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | KDM4E 2070/4885LMNA 3623/4885ALDH1A1 3068/4885 |
| US-11155551-B2 | Nicotinic acetylcholine receptor silent agonists | CHRNA7, CHRNA2, CHRNE | KDM4E 2070/4885LMNA 3623/4885ALDH1A1 3068/4885 |
| US-10662191-B2 | Nicotinic acetylcholine receptor silent agonists | CHRNA7, CHRNA2, CHRNE | KDM4E 2070/4885LMNA 3623/4885ALDH1A1 3068/4885 |
| US-20200247804-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | KDM4E 2070/4885LMNA 3623/4885ALDH1A1 3068/4885 |
| US-20210332046-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | KDM4E 2070/4885LMNA 3623/4885ALDH1A1 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.