Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | HEXA | P06865 | 1/20 | 0.42 |
| ▸ | HEXB | P07686 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747876 | 0.96 | KCNA3 (0.55) | ADRB2HTR1BKCNA3KDM4ESMN1; SMN2 | |
| SCHEMBL11605558 | 0.94 | KCNA3 (0.59) | ADRB2HTR1BKCNA3KDM4ESMN1; SMN2 | |
| SCHEMBL5749245 | 0.90 | HTR1B (0.56) | ADRB2HTR1BKCNA3KDM4ESMN1; SMN2 | |
| SCHEMBL5749560 | 0.85 | KCNA3 (0.55) | ADRB2HTR1BKCNA3KDM4ESMN1; SMN2 | |
| SCHEMBL5747505 | 0.84 | KCNA3 (0.57) | HTR1BKCNA3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL28498709 | 0.79 | KCNA3 (0.62) | KCNA3MEN1KMT2ATTRMAPT | |
| SCHEMBL7933560 | 0.77 | KCNA3 (0.59) | KCNA3KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL5745370 | 0.77 | KCNA3 (0.52) | HTR1BKCNA3KDM4EMEN1ALDH1A1 | |
| SCHEMBL28851017 | 0.77 | KCNA3 (0.58) | KCNA3MEN1KMT2ATTRPTPRC | |
| SCHEMBL28986871 | 0.76 | KCNA3 (0.70) | KCNA3KDM4ESMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |