Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | HEXA | P06865 | 1/20 | 0.44 |
| ▸ | HEXB | P07686 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748969 | 0.90 | ADRB2 (0.58) | HTR1BKCNA3KDM4EADRB2HEXA | |
| SCHEMBL5747876 | 0.86 | KCNA3 (0.55) | HTR1BKCNA3KDM4EADRB2SMN1; SMN2 | |
| SCHEMBL11605558 | 0.84 | KCNA3 (0.59) | HTR1BKCNA3KDM4EADRB2HEXA | |
| SCHEMBL5749560 | 0.84 | KCNA3 (0.55) | HTR1BKCNA3KDM4EADRB2SMN1; SMN2 | |
| SCHEMBL5747505 | 0.83 | KCNA3 (0.57) | HTR1BKCNA3KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL28498709 | 0.81 | KCNA3 (0.62) | KCNA3MEN1KMT2ATTR | |
| SCHEMBL28851017 | 0.78 | KCNA3 (0.58) | KCNA3MEN1KMT2ATTR | |
| SCHEMBL28986871 | 0.78 | KCNA3 (0.70) | KCNA3KDM4ESMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL28369285 | 0.77 | SLC2A1 (0.46) | HTR1BKCNA3KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL28374284 | 0.77 | SLC2A1 (0.46) | HTR1BKCNA3KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |