Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827047 | 1.00 | TSHR (0.44) | TSHRSMN1; SMN2PPARGPPARACETP | |
| SCHEMBL8045788 | 0.85 | CYP4F2 (0.56) | TSHRPPARGPPARACETPCYP4F2 | |
| SCHEMBL15604652 | 0.84 | F10 (0.43) | TSHRSMN1; SMN2PPARGPPARACETP | |
| SCHEMBL9621500 | 0.82 | KDM4E (0.45) | TSHRSMN1; SMN2PPARGPPARACETP | |
| SCHEMBL2903721 | 0.81 | MAOB (0.47) | SMN1; SMN2PPARGPPARACETPENPP2 | |
| SCHEMBL92907 | 0.81 | CETP (0.55) | CETP | |
| SCHEMBL14667219 | 0.81 | PPARA (0.43) | PPARGPPARACETPCMA1 | |
| SCHEMBL8048535 | 0.81 | CHRM2 (0.43) | PPARGPPARACETPCMA1 | |
| SCHEMBL3364653 | 0.81 | CETP (0.40) | TSHRSMN1; SMN2PPARGPPARACETP | |
| SCHEMBL6411834 | 0.81 | CETP (0.40) | PPARGPPARACETPCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158392-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2024-05-16 | — | — | US | disclosed |
| EP-4284801-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | Janssen Biotech, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| US-11780961-B2 | Organic metal-free catalysts with electrophilic and nucleophilic dual-functions, preparation methods of making the same, and uses thereof | ZHEJIANG UNIVERSITY (CN) | 2023-10-10 | — | — | US | disclosed |
| WO-2022165529-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | JANSSEN BIOTECH, INC. (US) | 2022-08-04 | — | — | WO | disclosed |
| US-20210363297-A1 | ORGANIC METAL-FREE CATALYSTS WITH ELECTROPHILIC AND NUCLEOPHILIC DUAL-FUNCTIONS, PREPARATION METHODS OF MAKING THE SAME, AND USES THEREOF | ZHEJIANG UNIVERSITY (CN) | 2021-11-25 | — | — | US | disclosed |
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| US-7541466-B2 | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases | GENZYME CORPORATION (US) | 2009-06-02 | — | — | US | disclosed |
| US-6982348-B2 | Aminoethanol derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-01-03 | — | — | US | disclosed |
| US-20040127574-A1 | Aminoethanol derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-07-01 | — | — | US | disclosed |
| EP-1362846-A1 | AMINOETHANOL DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-6566385-B2 | And the prenylation of the oncogene protein Ras; peptidomimetic macrocyclic compounds | MERCK & CO., INC. | 2003-05-20 | — | — | US | disclosed |
| US-20020099007-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-07-25 | — | — | US | disclosed |
| WO-2001051127-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| US-6106999-A | SENSITIVITY TO GENERAL-PURPOSE VISIBLE LIGHT LASER, SO THAT HIGH-SPEED SCANNING EXPOSURE IS POSSIBLE BY LASER, AND EXTREMELY FINE HIGH RESOLUTION CAN BE OBTAINED; CAN BE USED FOR COATING OR PRINTING UNDER SAFELIGHT IRRADIATING CONDITIONS | MITSUI CHEMICALS (JP) | 2000-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CYP3A5, CYP11B2, ABCB1 | TSHR 129/4885SMN1; SMN2 1130/4885PPARG 66/4885 |
| US-20040127574-A1 | Aminoethanol derivatives | CETP, LCAT, MTTP | TSHR 3729/4885SMN1; SMN2 4771/4885PPARG 905/4885 |
| US-20240158392-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | SIK2, SIK1, SGK2 | TSHR 4262/4885SMN1; SMN2 3223/4885PPARG 4017/4885 |
| US-20020099007-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | TSHR 3823/4885SMN1; SMN2 4670/4885PPARG 3902/4885 |
| US-11780961-B2 | Organic metal-free catalysts with electrophilic and nucleophilic dual-functions, preparation methods of making the same, and uses thereof | DUOX1, SOD1, DUOX2 | TSHR 4669/4885SMN1; SMN2 2861/4885PPARG 4421/4885 |
| US-20210363297-A1 | ORGANIC METAL-FREE CATALYSTS WITH ELECTROPHILIC AND NUCLEOPHILIC DUAL-FUNCTIONS, PREPARATION METHODS OF MAKING THE SAME, AND USES THEREOF | DUOX1, SOD1, DUOX2 | TSHR 4669/4885SMN1; SMN2 2861/4885PPARG 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.