Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768162 | 0.85 | SMN1; SMN2 (0.61) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6112657 | 0.85 | KMT2A (0.64) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19723534 | 0.84 | GAA (0.58) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL10511369 | 0.83 | POLB (0.64) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL20250793 | 0.81 | POLB (0.66) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17321417 | 0.81 | GAA (0.55) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6113039 | 0.80 | POLB (0.64) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19723588 | 0.80 | GAA (0.68) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1768201 | 0.79 | RAB9A (0.69) | GAAPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2937795 | 0.79 | KMT2A (0.73) | GAAPOLBSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913737-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-02-09 | — | — | US | disclosed |
| EP-3257854-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | University of Notre Dame du Lac (US) | 2017-12-20 | — | — | EP | disclosed |
| US-9309238-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-04-12 | — | — | US | disclosed |
| US-9309238-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-04-12 | — | — | US | disclosed |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | DOW AGROSCIENCES LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | DOW AGROSCIENCES LLC (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2011057145-A2 | IMIDAZO[1,2-A] PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-05-12 | — | — | WO | disclosed |
| EP-1682549-B1 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | SEPRACOR INC (US) | 2010-09-22 | — | — | EP | disclosed |
| US-7723324-B2 | Imidazo[1,2-A]pyridine anxiolytics | SEPRACOR, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7566725-B2 | Imidazo[1,2-A] pyridine anxiolytics | SEPRACOR INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20080096867-A1 | Imidazo[1,2-A] Pyridine Anxiolytics | SEPRACOR INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20070043074-A1 | IMIDAZO[1,2-A] PYRIDINE ANXIOLYTICS | SEPRACOR INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-7148353-B2 | Imidazo[1,2-a] pyridine anxiolytics | SEPRACOR INC. (US) | 2006-12-12 | — | — | US | disclosed |
| EP-1682549-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | Sepracor Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050171144-A1 | Imidazo[1,2-a] pyridine anxiolytics | SEPRACOR INC. (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005044818-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | SEPRACOR, INC. (US) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913737-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | RIF1, PYCR1, PNMT | GAA 1646/4885POLB 3367/4885SMN1; SMN2 3108/4885 |
| US-20070043074-A1 | IMIDAZO[1,2-A] PYRIDINE ANXIOLYTICS | CNR1, CNR2, GABRA5 | GAA 2781/4885POLB 4220/4885SMN1; SMN2 1946/4885 |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | RIF1, PYCR1, PNMT | GAA 1646/4885POLB 3367/4885SMN1; SMN2 3108/4885 |
| US-20050171144-A1 | Imidazo[1,2-a] pyridine anxiolytics | CNR1, CNR2, GABRA5 | GAA 2781/4885POLB 4220/4885SMN1; SMN2 1946/4885 |
| US-20080096867-A1 | Imidazo[1,2-A] Pyridine Anxiolytics | MTNR1B, ADORA2B, ADRA2B | GAA 2658/4885POLB 1180/4885SMN1; SMN2 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.