Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848592 | 0.88 | HTR2A (0.41) | HTR2ATAAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL112640 | 0.79 | LMNA (0.37) | ALDH1A1LMNA | |
| SCHEMBL30191342 | 0.79 | LMNA (0.37) | ALDH1A1LMNA | |
| SCHEMBL31260056 | 0.75 | APLNR (0.32) | — | |
| SCHEMBL14780348 | 0.67 | AOC3 (0.35) | — | |
| SCHEMBL6507540 | 0.64 | LMNA (0.34) | ALDH1A1LMNA | |
| SCHEMBL5794503 | 0.63 | PDXK (0.37) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2781560 | 0.63 | SLC6A2 (0.45) | HTR2ATAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6508612 | 0.63 | LMNA (0.37) | LMNA | |
| SCHEMBL19469845 | 0.63 | TAAR1 (0.45) | HTR2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658284-A1 | 3,5 DISUBSTITUTED INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR MEDIATING OR INHIBITING CELL PROLIFERATION | PFIZER INC. (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005009997-A1 | 3,5 DISUBSTITUTED INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR MEDIATING OR INHIBITING CELL PROLIFERATION | PFIZER INC. (US) | 2005-02-03 | — | — | WO | disclosed |