Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516808 | 0.79 | MAPT (0.32) | — | |
| SCHEMBL14822643 | 0.77 | CYP11B2 (0.35) | — | |
| SCHEMBL24595056 | 0.75 | GABRA1 (0.34) | — | |
| SCHEMBL112640 | 0.75 | LMNA (0.37) | LMNAPRKDC | |
| SCHEMBL30191342 | 0.75 | LMNA (0.37) | LMNAPRKDC | |
| SCHEMBL13920153 | 0.75 | SMN1; SMN2 (0.38) | LMNA | |
| SCHEMBL658808 | 0.73 | ERN1 (0.34) | LMNAPRKDC | |
| SCHEMBL1293137 | 0.71 | LMNA (0.41) | LMNAPRKDCALDH1A3 | |
| SCHEMBL20517931 | 0.69 | AOC3 (0.31) | — | |
| SCHEMBL18807881 | 0.69 | ERN1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | PFIZER INC | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, CDK4, CDK9 | LMNA 2990/4885PRKDC 202/4885ALDH1A3 1570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.