Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | EBP | Q15125 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752126 | 0.86 | SIGMAR1 (0.42) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL5753314 | 0.86 | ACHE (0.45) | SIGMAR1EBPCCR1CACNA1GCACNA1B | |
| SCHEMBL5751902 | 0.84 | SIGMAR1 (0.42) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL5753240 | 0.84 | SIGMAR1 (0.45) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL14431859 | 0.84 | CCR3 (0.54) | SIGMAR1EBPCCR1CCR3CACNA1B | |
| SCHEMBL21023241 | 0.83 | SIGMAR1 (0.52) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL11932001 | 0.83 | SIGMAR1 (0.52) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL5751875 | 0.82 | HTR1A (0.54) | SIGMAR1CACNA1GCACNA1BHTR7 | |
| SCHEMBL5751414 | 0.82 | CCR1 (0.45) | SIGMAR1EBPCCR1CACNA1GCCR3 | |
| SCHEMBL5240018 | 0.81 | RAB9A (0.52) | SIGMAR1EBPCCR1CCR3CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | claimed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | claimed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | claimed |
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |