SCHEMBL5755328

SCHEMBL5755328

C=CCC(C#N)(c1ccccc1)C(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EBP Q15125 2/20 0.48
SIGMAR1 Q99720 2/20 0.48
ALDH1A1 P00352 1/20 0.42
TSHR P16473 1/20 0.42
CYP2D6 P10635 4/20 0.41
CYP3A4 P08684 3/20 0.41
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.37
DRD2 P14416 1/20 0.37
DRD4 P21917 1/20 0.37
OPRM1 P35372 1/20 0.37
DRD3 P35462 1/20 0.37
ATM Q13315 2/20 0.36
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CHRM3 P20309 2/20 0.35
CHRM2 P08172 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7305092 0.85 EBP (0.47) EBPSIGMAR1ALDH1A1TSHRCYP2D6
SCHEMBL5243028 0.85 EBP (0.47) EBPSIGMAR1ALDH1A1TSHRCYP2D6
SCHEMBL7310837 0.83 EBP (0.52) EBPSIGMAR1ALDH1A1TSHRCYP2D6
SCHEMBL10715622 0.80 HTT (0.41) EBPSIGMAR1ALDH1A1TSHRCYP2D6
SCHEMBL10746527 0.80 ALDH1A1 (0.37) EBPSIGMAR1ALDH1A1TSHRCYP2D6
SCHEMBL7310097 0.80 EBP (0.43) EBPSIGMAR1TSHRCYP2D6CYP3A4
SCHEMBL7310100 0.80 EBP (0.43) EBPSIGMAR1TSHRCYP2D6CYP3A4
SCHEMBL7307228 0.80 EBP (0.55) EBPSIGMAR1TSHRCYP2D6CYP3A4
SCHEMBL8751192 0.79 L3MBTL1 (0.58) EBPSIGMAR1ALDH1A1TSHRL3MBTL1
SCHEMBL7314647 0.79 EBP (0.42) EBPSIGMAR1ALDH1A1TSHRCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1099692-B1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES EISAI CO LTD (JP) 2006-05-03 EP disclosed
US-6737425-B1 SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS EISAI CO., LTD. (JP) 2004-05-18 US disclosed
EP-1099692-A1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES Eisai Co., Ltd. (JP) 2001-05-16 EP disclosed
EP-0587625-B1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF VUFB AS (CZ) 1997-04-02 EP disclosed
EP-0587625-B1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF VUFB AS (CZ) 1997-04-02 EP disclosed
US-5424456-A N-arylalkylderivatives of 2-aminomethyl-2,3-dihydro-1,4-benzodioxine and the process of preparation thereof VYZKUMNY USTAV PRO FARMACII A BIOCHEMII S.P. (CS) 1995-06-13 US disclosed
US-5424456-A N-arylalkylderivatives of 2-aminomethyl-2,3-dihydro-1,4-benzodioxine and the process of preparation thereof VYZKUMNY USTAV PRO FARMACII A BIOCHEMII S.P. (CS) 1995-06-13 US disclosed
EP-0587625-A1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF. VYZK USTAV FARM BIOCHEM SP (CS) 1994-03-23 EP disclosed
EP-0587625-A1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF. VYZK USTAV FARM BIOCHEM SP (CS) 1994-03-23 EP disclosed
WO-1992021671-A1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF VYZKUMNY USTAV PRO FARMACII A BIOCHEMII, S.P. (CS) 1992-12-10 WO disclosed
WO-1992021671-A1 N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF VYZKUMNY USTAV PRO FARMACII A BIOCHEMII, S.P. (CS) 1992-12-10 WO disclosed