Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 17/20 | 0.44 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363480 | 0.82 | KIF11 (0.60) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL6206914 | 0.76 | KIF11 (0.55) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3961161 | 0.76 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4361632 | 0.75 | KIF11 (0.72) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5753789 | 0.75 | KIF11 (0.44) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4367396 | 0.75 | KIF11 (0.67) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5751482 | 0.73 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5396014 | 0.73 | KIF11 (0.59) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3961130 | 0.73 | KIF11 (0.53) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496287 | 0.73 | KIF11 (0.48) | KIF11MAP1LC3BKCNH2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |