Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756557 | 0.87 | DHFR (0.33) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5758291 | 0.81 | PDE4B (0.34) | PDE4BPDE4DPDE4AALDH1A1 | |
| SCHEMBL5757580 | 0.80 | PDE4B (0.34) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1157678 | 0.79 | CYP19A1 (0.39) | PDE4BMAPTMEN1KMT2APDE4D | |
| SCHEMBL5756332 | 0.78 | PDE4A (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3601944 | 0.78 | PDE4D (0.47) | PDE4BKDM4EUTS2RMAPTMEN1 | |
| SCHEMBL5755717 | 0.75 | PDE4B (0.44) | PDE4BPDE4DLMNAPDE4APDE4C | |
| SCHEMBL5757544 | 0.75 | PDE4A (0.41) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5756853 | 0.72 | AKT1 (0.36) | PDE4BKDM4EMAPTMEN1KMT2A | |
| SCHEMBL5759453 | 0.71 | PDE5A (0.38) | PDE4BKDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |