Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758859 | 0.89 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5758291 | 0.88 | PDE4B (0.34) | PDE4BPDE4DPDE4A | |
| SCHEMBL5756557 | 0.83 | DHFR (0.33) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5756853 | 0.83 | AKT1 (0.36) | PDE4BPDE4DPDE4AGSK3BKCNH2 | |
| SCHEMBL5758448 | 0.80 | PDE4B (0.40) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5759370 | 0.79 | PDE4A (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3605916 | 0.78 | PDE4D (0.49) | PDE4D | |
| SCHEMBL5755076 | 0.76 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5755717 | 0.74 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CIGF1R | |
| SCHEMBL5759453 | 0.74 | PDE5A (0.38) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |