Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.34 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759453 | 0.88 | PDE5A (0.38) | POLBLMNAL3MBTL1PDE4DPDE4B | |
| SCHEMBL5761077 | 0.88 | POLB (0.42) | AKT1POLBLMNAL3MBTL1P2RX7 | |
| SCHEMBL5757580 | 0.83 | PDE4B (0.34) | PDE4DPDE4BPDE4APDE4CGSK3B | |
| SCHEMBL3603395 | 0.80 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CGPR142 | |
| SCHEMBL5758291 | 0.75 | PDE4B (0.34) | PDE4DPDE4BPDE4AALDH1A1 | |
| SCHEMBL5756557 | 0.74 | DHFR (0.33) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5758859 | 0.73 | PDE4B (0.41) | LMNAPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5758448 | 0.72 | PDE4B (0.40) | POLBLMNAPDE4DPDE4BPDE4A | |
| SCHEMBL4178667 | 0.69 | PDE4D (0.46) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3605916 | 0.69 | PDE4D (0.49) | PDE4DMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |