Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30022945 | 0.75 | TGFBR1 (0.60) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL30787483 | 0.71 | TGFBR1 (0.55) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4806744 | 0.67 | CYP11B1 (0.53) | — | |
| SCHEMBL20550895 | 0.64 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL30023059 | 0.64 | PTGS2 (0.68) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18041502 | 0.64 | TGFBR1 (0.52) | TGFBR1TGFBR2 | |
| SCHEMBL996389 | 0.63 | MAPK14 (0.44) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL23795643 | 0.63 | MAPK14 (0.66) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4913956 | 0.63 | MAPK14 (0.64) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11175120 | 0.62 | MAPK14 (0.59) | TGFBR1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727541-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | Warner-Lambert Company LLC (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005079790-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-09-01 | — | — | WO | disclosed |