Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759227 | 0.80 | HPGD (0.53) | MAPTKMT2ALMNACNR2CNR1 | |
| SCHEMBL2736780 | 0.79 | CNR1 (0.57) | KMT2ALMNACNR2CNR1ALDH1A1 | |
| SCHEMBL11588063 | 0.70 | SLC16A3 (0.66) | MAPTKMT2ALMNAALDH1A1HSD17B10 | |
| SCHEMBL8300495 | 0.68 | KMT2A (0.65) | KMT2ALMNAALDH1A1HSD17B10HPGD | |
| SCHEMBL5760754 | 0.66 | LMNA (0.43) | KMT2ALMNACNR2CNR1ALDH1A1 | |
| SCHEMBL2914620 | 0.65 | KCNK3 (0.68) | MAPTKMT2ALMNAALDH1A1HPGD | |
| SCHEMBL29839397 | 0.65 | ALDH1A1 (0.47) | MAPTKMT2ALMNAALDH1A1HSD17B10 | |
| SCHEMBL22729752 | 0.65 | ALDH1A1 (0.47) | MAPTKMT2ALMNAALDH1A1HSD17B10 | |
| SCHEMBL23643039 | 0.65 | KMT2A (0.60) | MAPTKMT2AALDH1A1GAAPOLB | |
| SCHEMBL7183194 | 0.65 | MAPT (0.55) | MAPTKMT2ALMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | claimed |