Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760601 | 0.85 | RECQL (0.45) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL5760090 | 0.81 | ABCB1 (0.47) | LMNAKDM4EALDH1A1HTR1ADRD2 | |
| SCHEMBL5757406 | 0.80 | MAPT (0.55) | L3MBTL1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5757150 | 0.80 | MAPT (0.55) | L3MBTL1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5757409 | 0.80 | MAPT (0.55) | L3MBTL1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6626086 | 0.79 | HTR1A (0.47) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL5777034 | 0.78 | HTR1A (0.49) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL5754830 | 0.78 | RECQL (0.41) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL5754921 | 0.77 | MAPK1 (0.43) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL17313697 | 0.77 | KCNH2 (0.78) | L3MBTL1MAPTLMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343765-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERAZINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2006-11-22 | — | — | EP | claimed |