Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626086 | 0.81 | HTR1A (0.47) | HTR1AADRB1KDM4ELMNAALDH1A1 | |
| SCHEMBL5771426 | 0.81 | SLC2A1 (0.52) | HTR1AKDM4EALDH1A1HTTPOLB | |
| SCHEMBL5771419 | 0.81 | SLC2A1 (0.52) | HTR1AKDM4EALDH1A1HTTPOLB | |
| SCHEMBL5771425 | 0.81 | SLC2A1 (0.52) | HTR1AKDM4EALDH1A1HTTPOLB | |
| SCHEMBL5760090 | 0.80 | ABCB1 (0.47) | HTR1AKDM4ELMNAALDH1A1DRD2 | |
| SCHEMBL5760601 | 0.79 | RECQL (0.45) | HTR1AADRB1KDM4ELMNAALDH1A1 | |
| SCHEMBL5757154 | 0.78 | L3MBTL1 (0.54) | HTR1AADRB1KDM4ELMNAALDH1A1 | |
| SCHEMBL5754921 | 0.74 | MAPK1 (0.43) | HTR1AADRB1KDM4ELMNAALDH1A1 | |
| SCHEMBL5754830 | 0.74 | RECQL (0.41) | HTR1AADRB1KDM4ELMNAALDH1A1 | |
| SCHEMBL5776914 | 0.73 | MEN1 (0.40) | HTR1AADRB1KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343780-B1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF BACTERIAL INFECTIONS | SMITHKLINE BEECHAM PLC (GB) | 2006-09-20 | — | — | EP | claimed |