Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | EBP | Q15125 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754351 | 0.90 | SIGMAR1 (0.47) | SIGMAR1EBPTMEM97ADRA1DADRA1A | |
| SCHEMBL6626086 | 0.87 | HTR1A (0.47) | KDM4EALDH1A1LMNAADRA1DADRA1A | |
| SCHEMBL5757154 | 0.81 | L3MBTL1 (0.54) | KDM4EALDH1A1LMNAADRA1DADRA1A | |
| SCHEMBL5757405 | 0.80 | SLC2A1 (0.59) | SIGMAR1KDM4EALDH1A1HTR1A | |
| SCHEMBL5777034 | 0.80 | HTR1A (0.49) | KDM4EALDH1A1LMNAADRA1DADRA1A | |
| SCHEMBL5760601 | 0.79 | RECQL (0.45) | ABCB1KDM4EALDH1A1LMNAADRA1D | |
| SCHEMBL5776914 | 0.76 | MEN1 (0.40) | TMEM97KDM4EALDH1A1LMNAADRA1D | |
| SCHEMBL5754921 | 0.75 | MAPK1 (0.43) | ABCB1KDM4EALDH1A1LMNAADRA1D | |
| SCHEMBL5773715 | 0.75 | SLC2A1 (0.39) | TMEM97KDM4EALDH1A1ADRA1BDRD2 | |
| SCHEMBL6977618 | 0.75 | HTR4 (0.46) | TMEM97KDM4EALDH1A1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343765-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERAZINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2006-11-22 | — | — | EP | claimed |