SCHEMBL5757757

SCHEMBL5757757

NC(CCN1CCCCCC1)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.53
SIGMAR1 Q99720 1/20 0.50
CCR2 P41597 2/20 0.49
SLC6A3 Q01959 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
HIF1A Q16665 1/20 0.47
SLC22A1 O15245 1/20 0.47
CHRM2 P08172 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
CHRM1 P11229 1/20 0.47
DRD1 P21728 1/20 0.47
TBXA2R P21731 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
ADRA1A P35348 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6009479 1.00 ALDH1A1 (0.53) ALDH1A1SIGMAR1CCR2SLC6A3CYP1A2
Hydrochloric Acid SCHEMBL5756120 0.98 ALDH1A1 (0.51) ALDH1A1SIGMAR1CCR2SLC6A3CYP1A2
SCHEMBL28316666 0.98 ALDH1A1 (0.54) ALDH1A1SIGMAR1CCR2SLC6A3MEN1
SCHEMBL9796769 0.98 ALDH1A1 (0.54) ALDH1A1SIGMAR1CCR2SLC6A3MEN1
Hydrochloric Acid SCHEMBL5757965 0.96 ALDH1A1 (0.53) ALDH1A1SIGMAR1CCR2SLC6A3CYP3A4
Oxalic Acid SCHEMBL27277928 0.92 KMT2A (0.52) ALDH1A1CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL5757931 0.88 SIGMAR1 (0.53) SIGMAR1CYP1A2CYP3A4CYP2D6TSHR
Hydrochloric Acid SCHEMBL5760954 0.88 SIGMAR1 (0.49) SIGMAR1CYP1A2CYP3A4CYP2D6TSHR
Hydrochloric Acid SCHEMBL7250397 0.88 SIGMAR1 (0.49) SIGMAR1CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL6974535 0.88 LTA4H (0.55) SIGMAR1SLC6A3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401821-A4 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORP (KR) 2006-05-31 EP disclosed
EP-1401821-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK Corporation (KR) 2004-03-31 EP disclosed
WO-2002100848-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORPORATION (KR) 2002-12-19 WO disclosed
EP-0256181-B1 NOVEL QUINALDINAMIDE DERIVATIVES AND THEIR PREPARATIONS NIPPON CHEMIPHAR CO., LTD. (JP) 1991-01-23 EP disclosed
US-4764617-A MUSCLE RELAXANTS NIPPON CHEMIPHAR CO., LTD. (JP) 1988-08-16 US disclosed
EP-0256181-A1 Novel quinaldinamide derivatives and their preparations NIPPON CHEMIPHAR CO., LTD. (JP) 1988-02-24 EP disclosed