Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.35 |
| ▸ | RXRA | P19793 | 7/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758725 | 0.91 | SLC9A1 (0.36) | NR1H2NR1H3RXRAJAK2JAK1 | |
| SCHEMBL5761497 | 0.90 | STS (0.35) | ALDH1A1L3MBTL1NR1H2NR1H3RXRA | |
| SCHEMBL5760468 | 0.90 | JAK2 (0.35) | NR1H2NR1H3RXRAJAK2JAK1 | |
| SCHEMBL5756285 | 0.90 | HDAC3 (0.38) | NR1H2NR1H3RXRAJAK2JAK1 | |
| SCHEMBL5761284 | 0.87 | CHRNA7 (0.37) | SCN9ANR1H2NR1H3RXRAJAK2 | |
| SCHEMBL5760910 | 0.83 | CHRNA7 (0.36) | L3MBTL1NR1H2NR1H3RXRAJAK2 | |
| SCHEMBL5755024 | 0.83 | SLC6A2 (0.39) | L3MBTL1NR1H2NR1H3RXRAJAK2 | |
| SCHEMBL5754731 | 0.83 | ALDH1A1 (0.44) | ALDH1A1POLBCYP2C9NAMPTGPR119 | |
| SCHEMBL5755140 | 0.82 | ACACB (0.36) | ALDH1A1POLBL3MBTL1NR1H2NR1H3 | |
| SCHEMBL5759337 | 0.80 | L3MBTL1 (0.43) | POLBL3MBTL1NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144898-B2 | Indole derivatives for the treatment of depression and anxiety | ELI LILLY AND COMPANY (US) | 2006-12-05 | — | — | US | disclosed |
| EP-1242411-B1 | INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | LILLY CO ELI (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20040006229-A1 | Indole derivatives for the treatment of depression and anxiety | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006229-A1 | Indole derivatives for the treatment of depression and anxiety | IDO1, TPH1, IDO2 | ALDH1A1 101/4885POLB 3637/4885L3MBTL1 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.