SCHEMBL5758073

SCHEMBL5758073

Cc1cc2c(cc1C)NCCN2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.39
MAPT P10636 3/20 0.39
GAA P10253 3/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
KMT2A Q03164 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
ALDH1A1 P00352 4/20 0.35
HSD17B10 Q99714 3/20 0.35
HPGD P15428 3/20 0.33
LMNA P02545 1/20 0.33
ADRB1 P08588 1/20 0.32
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GRIN3A Q8TCU5 1/20 0.32
ADRA2A P08913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13092712 0.77 PARP10 (0.42) KDM4EMAPTGAAMEN1KMT2A
SCHEMBL8261456 0.76 DRD2 (0.47) KDM4EMAPTGAAALDH1A1HSD17B10
SCHEMBL3873979 0.73 KDM4E (0.42) KDM4EMAPTGAAMEN1NPC1
SCHEMBL10911472 0.73 ATM (0.53) KDM4EMAPTGAAALDH1A1HSD17B10
SCHEMBL11342856 0.71 ALDH1A1 (0.61) KDM4EMAPTGAAALDH1A1HSD17B10
SCHEMBL20153295 0.71 UHRF1 (0.39) UHRF1
SCHEMBL25156274 0.71 MAPT (0.45) KDM4EMAPTGAAALDH1A1HSD17B10
SCHEMBL10704285 0.70 MEN1 (0.37) GAAMEN1KMT2AALDH1A1UHRF1
SCHEMBL14467552 0.69 HPGD (0.42) KDM4EMAPTNPC1ALDH1A1HSD17B10
SCHEMBL26535454 0.69 UHRF1 (0.37) KDM4EMAPTGAAMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120131737-A Composition for improving immunity based on astragalus natural ingredients and preparation method thereof 蔓泰(北京)健康科技有限责任公司 2025-06-13 CN claimed
CN-120059665-A UV (ultraviolet) glue reducing adhesive and preparation method thereof 江西塔益莱高分子材料有限公司 2025-05-30 CN claimed
CN-118852803-A Wear-resistant carbon fiber synchronous belt and preparation method thereof 宁波伏龙同步带有限公司 2024-10-29 CN claimed
US-7101869-B2 2,4-diaminopyrimidine compounds useful as immunosuppressants PFIZER INC. (US) 2006-09-05 US claimed
EP-1242403-B1 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS PFIZER PROD INC (US) 2006-01-04 EP claimed
US-20030191307-A1 2,4-Diaminopyrimidine compounds useful as immunosuppressants BLUMENKOPF TODD A (US) 2003-10-09 US claimed
CN-1402720-A 2,4-diaminopyrimidine compounds useful as immunosuppressants PFIZER PROD INC (US) 2003-03-12 CN claimed
EP-1242403-A1 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS Pfizer Products Inc. (US) 2002-09-25 EP claimed
WO-2001040215-A1 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS PFIZER PRODUCTS INC. (US) 2001-06-07 WO claimed
CN-120131737-A Composition for improving immunity based on astragalus natural ingredients and preparation method thereof 蔓泰(北京)健康科技有限责任公司 2025-06-13 CN disclosed
CN-120059665-A UV (ultraviolet) glue reducing adhesive and preparation method thereof 江西塔益莱高分子材料有限公司 2025-05-30 CN disclosed
CN-119193029-A Highly stable anisotropic conductive adhesive film and preparation method thereof 古泰(江苏)新材料有限公司 2024-12-27 CN disclosed
CN-119144270-A Black no substrate net exhaust heat conduction double sided tape 江苏穗实科技有限公司 2024-12-17 CN disclosed
CN-118852803-B Wear-resistant carbon fiber synchronous belt and preparation method thereof 宁波伏龙同步带有限公司 2024-12-13 CN disclosed
CN-118852803-A Wear-resistant carbon fiber synchronous belt and preparation method thereof 宁波伏龙同步带有限公司 2024-10-29 CN disclosed
US-7101869-B2 2,4-diaminopyrimidine compounds useful as immunosuppressants PFIZER INC. (US) 2006-09-05 US disclosed
EP-1242403-B1 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS PFIZER PROD INC (US) 2006-01-04 EP disclosed
US-20030191307-A1 2,4-Diaminopyrimidine compounds useful as immunosuppressants BLUMENKOPF TODD A (US) 2003-10-09 US disclosed
CN-1402720-A 2,4-diaminopyrimidine compounds useful as immunosuppressants PFIZER PROD INC (US) 2003-03-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030191307-A1 2,4-Diaminopyrimidine compounds useful as immunosuppressants CCR1, AOC1, NOD1 KDM4E 2949/4885MAPT 4588/4885GAA 3686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.