Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | PPIB | P23284 | 2/20 | 0.51 |
| ▸ | PPID | Q08752 | 1/20 | 0.51 |
| ▸ | PPIG | Q13427 | 1/20 | 0.51 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194432 | 0.88 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1MEN1KMT2AROCK2 | |
| SCHEMBL5078499 | 0.81 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSD11B1MAOAMAOB | |
| SCHEMBL17093004 | 0.80 | RIPK1 (0.51) | HSP90AA1HSP90AB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30007971 | 0.78 | ROCK2 (0.47) | ROCK2SCD5SMN1; SMN2HSD11B1MAOA | |
| SCHEMBL11158709 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1MEN1KMT2APPIB | |
| SCHEMBL11662303 | 0.77 | HTR1A (0.48) | HSP90AA1HSP90AB1MEN1KMT2APPIB | |
| SCHEMBL1245060 | 0.77 | MEN1 (0.42) | HSP90AA1HSP90AB1MEN1KMT2APPIB | |
| SCHEMBL6310168 | 0.77 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1HSD11B1MAOAMAOB | |
| SCHEMBL16964986 | 0.76 | RIPK1 (0.48) | HSP90AA1HSP90AB1SMN1; SMN2HSD11B1ALDH1A1 | |
| SCHEMBL27223574 | 0.76 | BACE1 (0.40) | HSP90AA1HSP90AB1PPIBPPIDPPIG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622871-A1 | CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004099143-A1 | CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | disclosed |