Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114576 | 0.98 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1TSHRHTTGAA | |
| SCHEMBL5761769 | 0.96 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TSHRHTTGAA | |
| SCHEMBL2112891 | 0.85 | GRM2 (0.47) | ALDH1A1L3MBTL1TSHRHTTSMN1; SMN2 | |
| SCHEMBL20394335 | 0.74 | LMNA (0.48) | ALDH1A1TSHRHTTSMN1; SMN2GBA1 | |
| SCHEMBL12808838 | 0.72 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1TSHRHTTGAA | |
| SCHEMBL2111862 | 0.72 | TSPO (0.50) | ALDH1A1L3MBTL1TSHRGAASMN1; SMN2 | |
| SCHEMBL2113204 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HTTGAASMN1; SMN2MEN1 | |
| SCHEMBL7095387 | 0.69 | ALDH1A1 (0.60) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5762013 | 0.69 | EDNRA (0.33) | ALDH1A1 | |
| SCHEMBL18438489 | 0.68 | ALDH1A1 (0.62) | ALDH1A1GAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611091-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089885-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |