Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766338 | 0.88 | HSD11B1 (0.45) | HSD11B1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL4817084 | 0.87 | MAOA (0.45) | HSD11B1CYP2C9ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5766533 | 0.83 | MEN1 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL5766810 | 0.75 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL5765833 | 0.74 | HSD11B1 (0.41) | HSD11B1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL5776083 | 0.73 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL5775392 | 0.71 | NT5E (0.41) | HSD11B1MAPK14 | |
| SCHEMBL13385743 | 0.71 | HSD11B1 (0.53) | HSD11B1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL4072097 | 0.71 | HSD11B1 (0.49) | HSD11B1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL15007237 | 0.71 | HSD11B1 (0.52) | HSD11B1ALDH1A1LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |